Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

We performed genetic and cellular immunologic studies involving five unrelated children with early-onset invasive bacterial and viral infections, lymphopenia, and defective T-cell, B-cell, and natural killer (NK)–cell responses. Two patients died early in childhood; after allogeneic hematopoietic stem-cell transplantation, the other three had normalization of T-cell function and clinical improvement.

Website: http://www.arjonline.org/medicine-and-health-care/american-research-journal-of-gynecology/